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                师资介绍

                姓名:刘贻尧

                职位:生物技术系正高-教授、博导

                联系方式:liuyiyao@uestc.edu.cn

                个人背景 研究方向 科研项目 论文列表 教学工作 其他信息
                1994/09-1998/07 重庆大学材料科学与工程学院,材料工程,学士
                1998/09-2001/07 重庆大学生物工程学院,生物医学工程yb体育app|下载最新版yb体育app|下载最新版,硕士
                2001/09-2004/09 日本群马大学生物化学工程系yb体育app|下载最新版,生物物理,博士
                2004/09-2008/07 电子科技大学生命科学与技术学院,副教授
                2005/12-2007/09 日本德岛大学医学部yb体育app|下载最新版,博士后
                2009/12-2017/12 电子科技大学生命科学与技术学院,副院长
                2014/07-2014/08 德国卡尔斯鲁厄理工学院(KIT),访问教授
                2008/07-至今  电子科技大学生命科学与技术学院,教授/博士生导师
                1.肿瘤细胞力学与细胞信号转导
                2.肿瘤微纳医学工程与分子成像

                近年主持的主要科研项目: 1. 三维胞外基质粘弹性影响乳腺癌细胞凋亡和自噬交互作用的力学生物学机制研究,国家自然科学基金(no. 11772088) 2. 肿瘤微环境基质理化特性对肿瘤起始细胞上皮-间质转换调控的生物力学机制研究yb体育app|下载最新版,四川省科技厅应用基础研究项目(no. 2017JY0019) 3. 小窝蛋白-1在肿瘤细胞抗失巢凋亡力学信号转导中的功能与调控机制研究,国家自然科学基金(no. 31470906) 4. 基因与化疗药物共输送的PLGA超声纳米泡的构建及其协同抗肿瘤作用与超声成像规律研究,四川省杰出青年基金(2014JQ0008) 5. 剪切力调控肿瘤细胞粘附与迁移新机制:整合素alpha(v)beta(3)和GP IIb/IIIa作用规律及其力学生物学机制研究,国家自然科学基金(no. 11272083) 6. 生物-磁双重靶向Fe3O4@SiO2纳米荧光探针制备及其生物医学应用初步研究,国家自然科学基金(no.81071257) 7. 剪切流场下靶向抗-VCAM-1超声微泡在内皮细胞上的粘附规律及其在动脉粥样硬化检测中的应用yb体育app|下载最新版,国家自然科学基金(no. 30700151) 8. 多功能化荧光纳米探针的构建及其在心血管疾病早期诊断中的应用基础研究,教育部新世纪优秀人才支持计划(no. NCET-09-0263)



                已经发表SCI收录论文60余篇(*通讯作者)yb体育app|下载最新版,主要论文如下:(具体见实验室网站:http://biophysics.uestc.edu.cn)
                01. Li T, Shen X, Xie X, Chen Z, Li S, Qin X, Yang H, Wu C, Liu Y*. (2018) Irinotecan/IR-820 co-loaded hollow mesoporous silica nanoparticles as a platform for combinational chemotherapy and photothermal therapy of tumor. Nanomedicine. (accepted, in press) 
                02. Zhang J, Li L, Peng Y, Chen Y, Li S, Qin X, Yang H, Wu C, Liu Y*. (2018) Surface chemistry induces mitochondria-mediated apoptosis of breast cancer cells via PTEN/PI3K/AKT signaling pathway. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1865: 172-185. 
                03. Yang H, Zhang C, Li T, Shen X, Chen Z, Xie X, Li S, Qin X, Wu C, Liu Y*. (2017) Rational design of multifunctional polymeric micelles with stimuli-responsive property for imaging-guided combination cancer therapy. Journal of Biomedical Nanotechnology. 13(10): 1221-1234. 
                04. Li L, Tang P, Li S, Qin X, Yang H, Wu C, Liu Y*. (2017) Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy. Medical Oncology. 34:180. doi: 10.1007/s12032-017-1039-6. (invited review). 
                05. Li S, Lu J, Chen Y, Xiong N, Li L, Zhang J, Yang H, Wu C, Zeng H, Liu Y*. (2017) MCP-1-triggered ERK/GSK-3beta/Snail pathway facilitates epithelial- mesenchymal transition and promotes cell migration of human breast carcinoma MCF-7 cells. Cellular & Molecular Immunology. 14: 621-630. 
                06. Shen X, Li T, Chen Z, Geng Y, Xie X, Li S, Yang H, Wu C, Liu Y*. (2017) PLGA-based luminescent/magnetic hybrid nanocomposites: a versatile nanocarrier system for targeted drug/gene delivery and dual-modality imaging in cancer theranostics. International Journal of Nanomedicine. 12: 4299-4322. 
                07. Zhang G, Fan N, Lv X, Liu Y, Guo J, Yang L, Peng B*, Jiang H*. (2017) Investigation of the mechanical properties of human osteosarcoma cell at different cell cycle stages. Micromachines. 8(3), 89; DOI: 10.3390/mi8030089. 
                08. Yang H, Chen Y, Chen Z, Geng Y, Shen X, Li T, Li S, Wu C, Liu Y*. (2017) Chemo-photodynamic combined gene therapy and dual-modal cancer imaging achieved by pH-responsive alginate/chitosan multilayers-modified magnetic mesoporous silica nanocomposites. Biomaterials Science. 5: 1001-1013. 
                09. Wu C, Li D, Wang L, Guan X, Tian Y, Yang H, Li S, Liu Y*. (2017) Single wavelength light-mediated, synergistic bimodal cancer photoablation and amplified photothermal performance by graphene/gold nanostar/photosensitizer theranostics. Acta Biomaterialia. 53: 631-642. 
                10. Xiong N, Li S, Tang K, Bai H, Peng Y, Yang H, Wu C, Liu Y*. (2017). Involvement of caveolin-1 in low shear stress-induced breast cancer cell motility and adhesion: roles of FAK/Src and ROCK/p-MLC pathways. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1864: 12-22. 
                11. Jiang Y, Sverdlov MS, Toth PT, Huang L, Du G, Liu Y, Natarajan V, Minshall RD*. (2016) Phosphatidic acid produced by RalA-activated PLD2 stimulates caveolae-mediated endocytosis and trafficking in endothelial cells. Journal of Biological Chemistry. 291: 20729-20738. 
                12. Gao Z, Li T, Xu X, Liu Y, Luo H*, Li N*. (2016) Green light-emitting polyepinephrine-based fluorescent organic dots and its application in intracellular metal ions sensing. Biosensors and Bioelectronics. 83: 134-141. 
                13. Li T, Shen X, Geng Y, Chen Z, Li L, Li S, Yang H, Wu C, Zeng H, Liu Y*. (2016) Folate-functionalized magnetic-mesoporous silica nanoparticles for drug/gene co-delivery to potentiate the antitumor efficacy. ACS Applied Materials & Interfaces. 8: 13748-13758. 
                14. Yang H, Xu M, Shen X, Li T, Yan J, Zhang C, Wu C, Zeng H, Liu Y*. (2016) Chitosan hybrid nanoparticles as a theranostic platform for targeted doxorubicin/VEGF shRNA co-delivery and dual-modality fluorescence imaging. RSC Advances. 6: 29685-29696. 
                15. Yang H, Guan L, Li S, Jiang Y, Xiong N, Li L, Wu C, Zeng H, Liu Y*. (2016) Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo. Oncotarget. 7(13): 16227-16247. 
                16. Li L, Zhang J, Xiong N, Li S, Chen Y, Yang H, Wu C, Zeng H, Liu Y*. (2016) Notch-1 signaling activates NF-?B in human breast carcinoma MDA-MB-231 cells via PP2A-dependent PI3K/AKT pathway. Medical Oncology. 33:33. DOI: 10.1007/s12032-016-0747-7. 
                17. Wu M, Li T, Chen L, Peng S, Liao W, Bai R, Zhao X, Yang H, Wu C, Zeng H, Liu Y*. (2016) Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms. Journal of Ethnopharmacology. 180: 18-27. 
                18. Wu C, Zhu A, Li D, Wang L, Yang H, Zeng H, Liu Y*. (2016) Photosensitizer-assembled PEGylated graphene-copper sulfide nanohybrids as a synergistic near-infrared phototherapeutic agent. Expert Opinion on Drug Delivery. 13: 155-165. 
                19. Yang H, Deng L, Li T, Shen X, Yan J, Zuo L, Wu C, Liu Y*. (2015) Multifunctional PLGA nanobubbles as theranostic agents: Combining doxorubicin and P-gp siRNA co-delivery into human breast cancer cells and ultrasound cellular imaging. Journal of Biomedical Nanotechnology. 11: 2124-2136. 
                20. Li S, Zhang J, Yang H, Wu C, Dong X, Liu Y*. (2015) Copper depletion inhibits CoCl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail/Twist-mediated epithelial-mesenchymal transition. Scientific Reports. 5: 12410; DOI: 10.1038/srep12410. 
                21. Zeng H, Agyapong D.A.Y, Li C, Zhao R, Yang H, Wu C, Jiang Y, Liu Y*. (2015) A carcinoembryonic antigen optoelectronic immunosensor based on thiol-derivative-nanogold labeled anti-CEA antibody nanomaterial and gold modified ITO. Sensors & Actuators B: Chemical. 221: 22-27. 
                22. Li T, Shen X, Chen Y, Zhang C, Yan J, Yang H, Wu C, Zeng H, Liu Y*. (2015) Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and MR imaging. International Journal of Nanomedicine. 10: 4279-4291.
                23. Wu C, He Q, Zhu A, Li D, Xu M, Yang H, Liu Y*. (2014) Synergistic anticancer activity of photo- and chemo-responsive nanoformulation based on polylysine-functionalized graphene. ACS Applied Materials & Interfaces. 6(23): 21615-21623. 
                24. Yang H(#), Li Y(#), Li T, Xu M, Chen Y, Wu C, Liu Y*. (2014) Multifunctional core/shell Notch-1 siRNA carrier for targeted killing of breast cancer. Scientific Reports. 4: 7072; DOI: 10.1038/srep07072. 
                25. Li L, Zhao F, Lu J, Li T, Yang H, Wu C, Liu Y*. (2014) Notch-1 signaling promotes the malignant features of human breast cancer through NF-kB activation. PLoS ONE. 9(4): e95912. 
                26. Zhao F, Li L, Guan L, Yang H, Wu C, Liu Y*. (2014) Roles of GP IIb/IIIa and αvβ3 integrins in MDA-MB-231 cell invasion and shear flow-induced cancer cell mechanotransduction. Cancer Letters. 344: 62-73.  
                27. Deng L, Li L, Yang H, Li L, Zhao F, Wu C, Liu Y*. (2014) Development and optimization of doxorubicin loaded PLGA nanobubbles for drug delivery into HeLa cells. Journal of Nanoscience and Nanotechnology. 14: 2947-2954. 
                28. Wu C*, He Q, Zhu A, Yang H, Liu Y*. (2014) Probing the protein conformation and adsorption behaviors in nanographene oxide-protein complexes. Journal of Nanoscience and Nanotechnology. 14: 2591-2598.  
                29. Yang H, Shi M, Xu M, Li Y, Wu C, Liu Y*. (2013) Multifunctional silica nanoparticles as theranostic agents: combining VEGF gene delivery and dual-modality cellular imaging. Journal of Controlled Release. 172(1): e120-e121. 
                30. Yang H, Zhao F, Li Y, Xu M, Li L, Wu C, Miyoshi H, Liu Y*. (2013) VCAM-1-targeted core/shell nanoparticles for selective adhesion and delivery to endothelial cells with lipopolysaccharide-induced inflammation under shear flow and cellular magnetic resonance imaging in vitro. International Journal of Nanomedicine. 8: 1897-1906. 
                31. Liu Y*, Shi M, Xu M, Yang H, Wu C. (2012) Multifunctional nanoparticles of Fe3O4@SiO2(FITC)/PAH conjugated the recombinant plasmid of pIRSE2-EGFP/VEGF165 with dual functions for gene delivery and cellular imaging. Expert Opinion on Drug Delivery. 9(10): 1197-1207. 
                32. Yang H, Zhang L, Xiong X, Liu Y*. (2011) Specific adhesion and accumulation of VCAM-1-targeted ultrasound microbubbles to inflammatory endothelial cells under hemodynamic shear flow simulation. Journal of Controlled Release. 152(s1): e227-e229. 
                33. Shi M, Liu Y*, Xu M, Yang H, Wu C, Miyoshi H. (2011) Core/shell Fe3O4@SiO2 nanoparticles modified with PAH as a vector for EGFP plasmid DNA delivery into HeLa cells. Macromolecular Bioscience. 11: 1563-1569. 
                34. Yang H(#), Lou C(#), Xu M, Wu C, Miyoshi H, Liu Y*. (2011) Investigation of folate conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism. International Journal of Nanomedicine. 6: 2023-2032. 
                35. Yang H, Xiong X, Zhang L, Wu C, Liu Y*. (2011) Adhesion of bio-functionalized ultrasound microbubbles to endothelial cells by targeting to vascular cell adhesion molecule-1 under shear flow. International Journal of Nanomedicine. 6: 2043-2051. 
                36. Liu Y*, Lou C, Yang H, Shi M, Miyoshi H. (2011) Silica nanoparticles as potential drug/gene delivery carriers and fluorescent nano-probes: recent advances. Current Cancer Drug Targets. 11: 156-163.  
                37. Xiong X, Zhao F, Shi M, Yang H, Liu Y*. (2011) Polymeric microbubbles for ultrasonic molecular imaging and targeted therapeutics. Journal of Biomaterials Science-Polymer Edition. 22: 417-428. 
                38. Meng G, Liu Y*, Lou C, Yang H. (2010) Emodin suppresses lipopolysaccharide-induced pro-inflammatory responses and NF-kB activation by disrupting lipid rafts in CD14-negative endothelial cells. British Journal of Pharmacology. 161: 1628-1644. 
                39. Yang H, Liu Z, Liu Y*, Lou C, Ren Z, Miyoshi H. (2010) Vascular gene transfer and drug delivery in vitro using low frequency ultrasound and microbubbles. Acta Pharmacologica Sinica. 31: 515-522.
                40. Yang H, Miyoshi H, Lou C, Ren Z, Liu Y*. (2010) Preparation, characterization and release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA. Chinese Science Bulletin. 55: 263-267. 
                41. Liu Y*, Zhao F, Gu W, Yang HS, Meng Q,  Zhang Y, Yang H, Duan Q. (2009) The Roles of Platelet GPIIb/IIIa and αvβ3 integrins during HeLa cells adhesion, migration, and invasion to monolayer endothelium under static and dynamic shear flow. Journal of Biomedicine and Biotechnology. DOI: 10.1155/2009/829243. 
                42. Miyoshi H,* Matsuo Y, Liu Y*, Sakata T, Mori H. (2009) Behaviors of the fluorescent molecules bound to the interior of the silica nanocapsules in various solvents. Journal of Colloid and Interface Science. 331: 507-513. 
                43. Yang H, Li K, Liu Y*, Liu Z, Miyoshi H. (2009) Poly(D,L-lactide-co-glycolide) nanoparticles encapsulated fluorescent isothiocyanate and paclitaxol: preparation, release kinetics and anticancer effect. Journal of Nanoscience and Nanotechnology. 9: 282-287. 
                44. Liu Y*, Miyoshi H. (2008) Preparation and characterization of novel drug delivery system of light-sensitive silica nanocapsules with thin shells. Journal of Biomedical Nanotechnology. 4: 25-32. 
                45. Guo Z, Cai SX, Fang R, Chen H, Du J, Tan Y, Ma W, Hu H, Cai SH, Liu Y*. (2007) The synergistic effects of CXCR4 and EGFR on promoting EGF-mediated metastasis in ovarian cancer cells. Colloids and Surfaces B: Biointerfaces. 60: 1-6. 
                46. Liu Y*, Miyoshi H, Nakamura M. (2007) Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis by targeted functional nanoparticles. International Journal of Cancer. 120: 2527-2537. 
                47. Liu Y*, Miyoshi H, Nakamura M. (2007) Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: Preparation and fluorescein isothiocyanate (FITC) release kinetics. Colloids and Surfaces B: Biointerfaces. 58: 180-187. 
                48. Liu Y*, Miyoshi H, Nakamura M. (2006) Encapsulated ultrasound microbubbles: therapeutic application in drug/gene delivery. Journal of Controlled Release. 114: 89-99. 
                49. Liu Y* Yang H, Su Q, Sakanishi A. (2006) Influence of parenteral fat emulsion Intralipos and citric acid on blood viscosity and erythrocyte morphology in vitro. Colloids and Surfaces B: Biointerfaces. 53: 51-54. 
                50. Liu Y*, Yang H, Takatsuki H, Sakanishi A. (2006) Effect of ultrasonic exposure on Ca2+-ATPase activity in plasma membrane from Aloe arborescens callus cells. Ultrasonics Sonochemistry. 13: 232-236. 
                51. Liu Y*, Yang H, Sakanishi A. (2006) Ultrasound: mechanical gene transfer into plant cells by sonoporation. Biotechnology Advances. 24: 1-16. 
                52. Liu Y, Uno H, Takatsuki H, Hirano M, Sakanishi A. (2005) Interrelation between HeLa-S3 cell transfection and hemolysis in red blood cell suspension using pulsed ultrasound of various duty cycles. European Biophysics Journal with Biophysics Letters. 34:163-169. 
                53. Liu Y*, Yang H, Otaka K, Takatsuki H, Sakanishi A. (2005) Effects of vascular endothelial growth factor (VEGF) and chondroitin sulfate on human monocytic THP-1 cell migration. Colloids and Surfaces B: Biointerfaces. 43: 216-220.
                本科生:分子生物学(双语教学)
                研究生:生物力学与组织工程学
                地  址:四川省成都市建设北路2段4号
                            电子科技大学 生命科学与技术学院
                电  话:028-83203353(办);028-83208238(传真)
                E-mail:  liuyiyao@uestc.edu.cn  
                欢迎访问实验室网站:http://biophysics.uestc.edu.cn
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